The presence of ANA is indicative of numerous disease states including Systemic Lupus Erythematosus (SLE), Mixed Connective Tissue Disease (MCTD), Rheumatoid Arthritis, Sjögren's Syndrome and other rheumatoid diseases. Low titer ANA (<=1:160) may also be seen in the elderly, transiently during viral infection and in otherwise healthy individuals; these ANA titers are of unknown significance. The absence of ANA is strong evidence against untreated SLE. The ANA screen includes screening for centromere antibody. If ANA screen is positive a titer and pattern will be performed at an additional charge.

This test is approved for New York patient testing.