Oligoclonal Bands (IgG), CSF  

Multiple, discrete oligoclonal IgG bands are present in the CSF of patients with multiple sclerosis (75%-95%) and other subacute or chronic inflammatory neurologic disorders (25%-35%) such as neurosyphilis, subacute sclerosing panencephalitis, meningitis, encephalitis, Guillain-Barré Syndrome and toxoplasmosis. Neither the number nor the pattern of bands correlates with the severity or activity of MS. The presence of oligoclonal IgG bands is a more sensitive indicator of MS than either myelin basic protein (MBP) or the IgG index. Oligoclonal bands are more specific for MS than MBP but less specific than the IgG index.

Test performed at Quest Diagnostics Nichols Institute.

  IEF (Isoelectric Focusing)
Reference Range
  No bands
Preferred Specimen
  1 mL CSF
(minimum 0.5 mL)
1 mL serum
(minimum 0.5 mL)
Collection date and time should be the same for both the CSF and Serum.
Transport Temperature
  2-8° C
Results Available
  3 to 6 days
CPT Code




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