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Reference Laboratory
Tests 		 
48833
Klebsiella pneumoniae Carbapenemase (KPC) Gene, Real-Time PCR - NEW! print

Carbapenem-resistance among Enterobacteriaceae, in particular among Klebsiella pneumoniae and E. coli, is an emerging problem worldwide and has become endemic in certain regions of the United States. Resistant K. pneumoniae (KPC-positive) strains tend to be highly resistant to multiple classes of antibiotics and have been associated with extremely high mortality rates. Real-time PCR assays for the detection of blaKPC genes will help in rapidly identifying colonized or infected patients.

This test is not approved for New York patient testing.
Methodology Real-Time Polymerase Chain Reaction
Reference Range Not detected
Preferred Specimen Pure bacterial isolate
Transport Temperature Room temperature
Results Available 1 to 3 days
CPT Code 87999
 
20376
Lymphocyte Subset Panel 3 print

Panel includes quantitation of total T cells (CD3), T helper cells (CD4), T suppressor cells (CD8), and T helper: T suppressor cell ratio. The quantitation of T cell subsets is useful for the evaluation of various immunodeficiency disorders, acquired immunodeficiency disease and evaluation of antiviral therapy.

Test performed at Quest Diagnostics Nichols Institute.
Methodology Flow Cytometry
Reference Range By report
Preferred Specimen 5 mL whole blood (EDTA)
(minimum 0.5 mL)
Transport Temperature Room temperature. DO NOT REFRIGERATE OR FREEZE.
Results Available 2 to 4 days
CPT Code 86359; 86360
 
51010
Legionella Antigen, EIA (Urine) print

Legionella pneumophila is responsible for 80-85% of reported cases of Legionella infections in the United States, and most of these infections are caused by L. pneumophila serogroup 1. The detection of L. pneumophila serogroup 1 soluble antigen in urine by EIA is a highly sensitive and specific method for the laboratory diagnosis of infection in these cases. L. pneumophila serogroup 1 antigenuria can occur 2-3 days after infection and may persist for prolonged periods after treatment in some patients. A negative test result does not rule out the possibility of infection due to other serogroups or Legionella species, since this test only detects L. pneumophila serogroup 1 antigen.

This test is approved for New York patient testing.
Methodology EIA (Enzyme Immunoassay)
Reference Range Negative
Preferred Specimen 5 mL urine, first void preferred
(minimum 0.5 mL)
Transport Temperature <=14 days post collection: 2-8° C.
>14 days post collection: FROZEN
Results Available 1 to 8 days
CPT Code 87449
 
52800
Lactoferrin Detection, EIA (Stool) print

Human lactoferrin is secreated by most mucosal membranes and is a major component of polymorphonuclear leukocytes during an inflammatory response. During intestinal inflammation, leukocytes migrate to the mucosa and infiltrate the intestinal lumen, increasing the level of fecal lactoferrin. Inflammatory bowel disease (IBD) is comprised of ulcerative colitis and Crohn's disease, both of which are highly inflammatory and are diagnosed by ruling out infectious agents and other potential causes of inflammation. This test for the qualitative detection of elevated levels of fecal lactoferrin can help to identify patients with active IBD and rule out those with active irritable bowel syndrome, which does not involve intestinal inflammation. This test can also be used as an indicator of inflammatory diarrhea caused by the presence of a bacterial pathogen. A positive test result indicates that the specimen contains elevated levels of lactoferrin.

This test is approved for New York patient testing.
Methodology EIA (Enzyme Immunoassay)
Reference Range Negative
Preferred Specimen 1 gram fresh unpreserved stool <=48 hours post collection
(minimum 1 gram)
Transport Temperature Refrigerate at 2-8° C if testing within 48 hours. FROZEN at
-20° C to -70° C if testing beyond 48 hours. Specimens that have been collected or stored in 10% Formalin, SAF, or PVA fixatives are not acceptable. Use of Cary-Blair transport medium is not acceptable.
Results Available 1 to 4 days
CPT Code 83630
 
56175
Levofloxacin Level, BA print

Specimens collected just before or within 15 minutes of the next dose represent the TROUGH levels. Specimens obtained within 15-30 minutes after the end of I.V. infusion or 45-60 minutes after an IM injection or 90 minutes after oral intake represent the PEAK level.

Normal Therapeutic Levels (500 mg qd):
 Peak serum5.7mcg/mL PO;6.4 mcg/mL IV
 Trough serum0.5mcg/mL PO;0.6 mcg/mL IV

Note: Any undisclosed antibiotics might affect the results.

List all other antimicrobials being used to treat the patient.

This test is available for New York patient testing.



Please see the following technical sheet for more information:
 Antimicrobial Testing
Methodology Bioassay
Reference Range By report
Preferred Specimen 1 mL serum
(minimum 0.5 mL)
Red Top serum separator tubes not acceptable.
Transport Temperature FROZEN
Results Available 3 to 4 days
CPT Code 80299
 
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-139
LA Antibodies (See SS-A and SS-B IgG Antibodies) print

 
51700
Legionella Culture print

Specimens are cultured on non-selective buffered CYE and on selective CYE. Cultures are held for up to 10 days. Positive cultures are speciated and serotyped when possible. Culture is more sensitive than the DFA test.

This test is approved for New York patient testing.
Methodology Culture
Reference Range None isolated
Preferred Specimen Clinical specimen properly collected. Refer to Microbiology Specimen Collection and Transport Guide.
Transport Temperature 2-8° C
Results Available 10 to 13 days
CPT Code 87081
 
-140
Lacrosse Virus (See California Encephalitis Virus) print

 
20384
Lymphocyte Subset Panel 2 print

Panel includes total T cells (CD3) and total B cells (CD19), T helper cells (CD4) and T suppressor cells (CD8). The panel is useful for the evaluation of immunodeficiency disease.

Test performed at Quest Diagnostics Nichols Institute.
Methodology Flow Cytometry
Reference Range By report
Preferred Specimen 5 mL whole blood (EDTA)
(minimum 0.5 mL)
Transport Temperature Room temperature. DO NOT REFRIGERATE OR FREEZE.
Results Available 2 to 4 days
CPT Code 86355; 86359; 86360
 
51705
Legionella Culture and Direct Detection, DFA print

Smears are stained with fluorescent monoclonal antisera that will detect the presence of Legionella pneumophila in clinical specimens. All serogroups of L. pneumophila will be detected. Specimens are cultured on non-selective buffered CYE and on selective CYE. Cultures are held for up to 10 days. Positive cultures can be further speciated and serotyped upon request. Refer to Unit Code 51701, Legionella Serotyping/Speciation.

This test is approved for New York patient testing.
Methodology Direct Fluorescent Antibody
Reference Range Not detected/none isolated
Preferred Specimen Clinical specimen properly collected. Refer to Microbiology Specimen Collection and Transport Guide.
Transport Temperature 2-8° C
Results Available 10 to 13 days
CPT Code 87081; 87278
 
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43155
Lambda Light Chain Quantitation, NEPH (Urine) print

Both bound and free light chains in urine are detected by nephelometry; bound light chains are still linked to heavy chains of specific immunoglobulins (IgG, IgA, IgM). Approximately 25% of patients with multiple myeloma secrete free light chains only, and another 25% secrete free light chains plus bound light chains. An immunoglobulin evaluation test is recommended to identify and characterize any associated paraprotein.

This test is approved for New York patient testing.
Methodology Nephelometry
Reference Range <2.0 mg/dL
Preferred Specimen 5 mL urine
(minimum 5 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 83883
 
51710
Legionella Culture, Environmental print

In order to increase sensitivity in isolation rates concentration techniques, pretreatment, and selective media are employed. Positive cultures are speciated and serotyped when possible.

Not for Clinical Specimens.

This test is approved for New York patient testing.
Methodology Culture
Reference Range None isolated
Preferred Specimen Adequate quantity or volume of environmental sample.
(minimum 200-500 mL standing water to 1 liter clear water).
Transport Temperature 2-8° C
Results Available 21 to 28 days
CPT Code Not applicable
 
51702
Legionella Identification Screen, Culture and DFA print

Isolates are confirmed as being Legionella and are then further identified as either "pneumophila" or "non-pneumophila" by staining with fluorescent monoclonal antibody. No further speciation is performed.

This test is approved for New York patient testing.
Methodology Culture and Direct Fluroescent Antibody
Reference Range By report
Preferred Specimen Pure culture safely contained.
Transport Temperature Room temperature
Results Available 2 to 5 days
CPT Code 87081; 87140
 
51005
Legionella pneumophila Direct Detection, DFA print

Smears are stained with fluorescent monoclonal antisera that will detect the presence of Legionella pneumophila in clinical specimens. All serogroups of L. pneumophila will be detected. Compared with culture using currently available media, the DFA has a low sensitivity (25%-70%) and a high specificity (>95%). Therefore it is recommended that the DFA test for L. pneumophila be used in conjunction with culture, not in place of it. This test can also be used to detect and identify L. pneumophila submitted in pure culture.

This test is approved for New York patient testing.
Methodology Direct Fluorescent Antibody
Reference Range Not detected
Preferred Specimen Clinical specimen on 2 heat
fixed slides, or clinical specimen
(minimum 2 mL), or pure culture safely contained.
Transport Temperature 2-8° C
Results Available 1 to 3 days
CPT Code 87278
 
47500
Legionella DNA, Qualitative Real-Time PCR print

This assay detects and differentiates between Legionella pneumophila and non-pneumophila Legionella spp DNA in clinical specimens.

This test is approved for New York patient testing.
Methodology Real-Time PCR
Reference Range Not detected
Preferred Specimen 1 mL bronchial wash/lavage or sputum
(minimum 0.3 mL)
OR
Throat swab or nasopharyngeal swab in 3 mL
(minimum 0.35 mL)
M4 media or V-C-M medium (green-cap) tube or equivalent
Transport Temperature 2-8° C
Results Available 1 to 3 days
CPT Code 87541; 87798
 
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40605
Legionella pneumophila Antibodies (IgM) print

The IgM response in legionellosis patients tends to develop concurrently with the IgG response and may remain positive for many months. IgM responses should be confirmed by demonstrating a significant polyvalent antibody response.

This test is approved for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range Legionella sp (non-pneumophila) <1:256
L. pneumophila <1:16
Preferred Specimen 1 mL serum
(minimum 0.1 mL)
Transport Temperature Room temperature
Results Available 1 to 4 days
CPT Code 86713 x 2
Sample Report(s) Positive
Negative
 
51701
Legionella Serotyping/Speciation print

Specific Legionella antisera is used to identify and serotype L. pneumophila isolates or to speciate non-L. pneumophila isolates.

This test is available for New York patient testing.
Methodology Immunofluorescence
Reference Range By report
Preferred Specimen Pure culture safely contained.
Transport Temperature Room temperature
Results Available 1 to 6 days
CPT Code 87140 x 15
 
40600
Legionella Antibody Panel, IFA print

Serum specimens are titered by indirect immunofluorescence against many immunotypes of Legionella spp. A four-fold or greater increase in titer between acute and convalescent sera provides evidence of recent infection.

This test is approved for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range L. pneumophila (serogroup 1): <1:16
L. pneumophila (serogroup 2-6): <1:16
Legionella species (non-pneumophila): <1:64
Preferred Specimen 1 mL serum
(minimum 0.1 mL)
Transport Temperature Room temperature
Results Available 1 to 4 days
CPT Code 86713 x 2
Sample Report(s) Positive
Negative
 
40610
Leishmania Antibody, IFA print

Panel includes titers against Leishmania donovani, L. mexicana, L. tropica and L. braziliensis. Titers >=1:16 are considered positive. The diagnosis of dermal or cutaneous leishmaniasis is more difficult than the visceral form, since a detectable immune response is often absent. Also, since crossreactions may occur (e.g., Chagas' disease, malaria, schistosomiasis), positive results provide only suggestive support for the diagnosis.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range IgG <1:16
IgM <1:20
Preferred Specimen 1 mL serum
(minimum 0.075 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 86717 x 8
 
40615
Leptospira Antibody Screen with Reflex to Titer, IHA print

The IHA procedure utilizes a leptospiral genus-specific antigen and is reactive with serotypes associated with disease in the U.S. Negative titers rule out the diagnosis of leptospirosis with 92% accuracy. Specificity of this test is 95% compared with MAT. All positive screening results will reflex to Leptospira Antibody Titer, IHA for an additional charge.

This test is approved for New York patient testing.
Methodology IHA (Indirect (Passive) Hemagglutination)
Reference Range Negative
Preferred Specimen 0.5 mL serum
(minimum 0.2 mL)
Transport Temperature Room temperature
Results Available 1 to 4 days
CPT Code 86720 (Add 86720 if reflexed)
 
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52015
Leptospira Culture and Stain, FM print

During week one of disease, Leptospires are most successfully detected by culture of blood and CSF. After this time and for several months thereafter, Leptospires may be intermittently shed in the urine. Spinal fluid obtained during the acute phase of the disease can also be cultured.

This test is approved for New York patient testing.
Methodology Culture and Fluroescent Microscopy
Reference Range None isolated
Preferred Specimen 10mL heparinized (or oxalate or citrate) blood or CSF first week of illness; after first week, 10 mL urine (neutralized, pH 7.0, by adding either a sterile weak acid or base solution).
Transport Temperature Room temperature
Results Available 28 to 30 days
CPT Code 87081; 87206
 
21442
Leukocyte Adhesion Deficiency (LAD) Evaluation, FC print

LAD is an autosomal recessive immunodeficiency disorder associated with recurrent bacterial and fungal infections. Two forms of LAD have been described. LAD-1 is associated with defective expression of CD18 by neutrophils, whereas LAD-2 is associated with defective expression of CD15s (sialyl-Lewis X). Specimen be received in our laboratory within 72 hours of collection.

This test is not approved for New York patient testing.
Methodology Flow Cytometry
Reference Range >= 90%
Preferred Specimen 7 mL Heparinized whole blood
(minimum 3 mL)
Received in our laboratory within 72 hours of collection.
(Note: EDTA and ACD are NOT accepted.)
Transport Temperature Room temperature
Results Available 1 to 3 days
CPT Code 88184; 88185
 
20106
Limulus Amebocyte Lysate (LAL) Assay, Quantitative print

A colorimetric assay detects and quantitates gram-negative endotoxin in aqueous solutions used in patient management. PLEASE GIVE NAME OF AQUEOUS SOLUTION, THE DILUENT IF APPLICABLE AND THE USP ENDOTOXIN LIMIT. Based on the information supplied, the appropriate specimen dilution will be prepared and tested. If required, additional dilutions will be performed for an additional charge.

Not for Clinical Specimens.

This test is approved for New York patient testing.
Methodology Chromogenic Assay
Reference Range <0.05 EU/mL
Preferred Specimen 5 mL aqueous solution used in patient management, in a non-pyrogenic, plastic container
(minimum 3 mL)
NO BODY FLUIDS OR GLASS VIALS ACCEPTED.
Transport Temperature FROZEN
Results Available 1 to 4 days
CPT Code Not applicable
 
-143
Listeria monocytogenes Culture (See Bacterial Culture, Aerobic, Special) print

 
10022
Listeria Antibody, CF (Serum) print

Single titers >=1:8 are suggestive of listeria infection. A four-fold or greater increase in titer between acute and convalescent specimens confirms the diagnosis.

This test is approved for New York patient testing.
Methodology CF (Complement Fixation)
Reference Range <1:8
Preferred Specimen 1 mL serum
(minimum 0.5 mL)
Transport Temperature 2-8° C
Results Available 2 to 5 days
CPT Code 86609
 
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60022
Listeria Antibody, CF (CSF) print

Detection of intrathecally-produced organism-specific antibodies in CSF indicates central nervous system infection. However, serum levels of organism-specific antibodies, blood-brain barrier integrity, and possible CSF contamination by blood should be considered when assessing CSF results.

This test is approved for New York patient testing.
Methodology Complement Fixation
Reference Range <1:1
Preferred Specimen 1 mL CSF
(minimum 0.5 mL)
Transport Temperature 2-8° C
Results Available 2 to 5 days
CPT Code 86609
 
20199
Liver-Kidney Microsomal Type 1 Antibody, ELISA print

Liver-kidney microsomal type 1 (LKM1) antibodies are found in patients with autoimmune hepatitis type 2 (AIH2), and occasionally in patients with hepatitis C virus infection. AIH2 patients are typically teenagers or young adults, and experience clinically aggressive disease with an unfavorable prognosis. LKM1 antibodies recognize cytochrome P4502D6 protein, a component of smooth endoplasmic reticulum.

This test is approved for New York patient testing.



Please see the following technical sheet for more information:
 Autoantibodies Associated with Autoimmune Hepatitis
Methodology ELISA (Enzyme Linked Immunosorbent Assay)
Reference Range <=20.0 units
Preferred Specimen 0.5 mL serum
(minimum 0.2 mL)
Transport Temperature 2-8° C
Results Available 1 to 8 days
CPT Code 86376
 
2180
Lupus/ANA Panel print

See individual assay for description.

Panel Includes:

  • ANA IFA Screen with Reflex to Titer and Pattern
  • C3, Complement NEPH
  • C4, Complement NEPH
  • Centromere Antibody, IFA
  • dsDNA Antibody (native), MAID
  • RNP and Sm Antibodies IgG, MAID
  • SS-A and SS-B IgG Antibodies, MAID

Methodology IFA (Immunofluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range By report
Preferred Specimen 3 mL serum
(minimum 1.5 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 86039; 86160 x 2; 86225; 86235 x 4
 
10023
Lupus Anticoagulant (DRVVT) print

This unit code has been inactivated.

Please see unit code 1023.
 
1023
Lupus Anticoagulant Evaluation with Reflexes print

This is a multi-step coagulation test, including Partial Thromboplastin Time- Lupus Anticoagulant (PTT-LA) and dilute Russel’s viper venom (dRVVT). If the clotting time(s) are prolonged, additional confirmation tests are performed, i.e. hexagonal phase neutralization test and/or phospholipid neutralization, to determine if the prolonged clotting is due to lupus anticoagulant.

If the PTT-LA test is prolonged >40 seconds, the Hexagonal Phase Neutralization is performed at an additional charge. If the dRVVT Screen is prolonged >42 seconds, the dRVVT Confirmation is performed at an additional charge. If the dRVVT Confirmation is positive a dRVVT 1:1 dilution is performed at an additional charge.

Test performed at Quest Diagnostics Nichols Institute.
Methodology Photo-optical Clot Detection
Reference Range By report
Preferred Specimen 3 mL plasma 3.2 % sodium citrate (light blue-top)
(minimum 2 mL)
Transport Temperature FROZEN
Results Available 3 to 6 days
CPT Code 85597 x 2; 85613 x 3; 85730
 
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22200
Lupus Comprehensive Panel print

See individual assay for description.

Panel Includes:

  • Actin (Smooth Muscle) IgG, ELISA
  • ANA IFA Screen with Reflex to Titer and Pattern
  • C3, Complement NEPH
  • C4, Complement NEPH
  • dsDNA Antibody, MAID
  • Mitochondria M2 Antibody (IgG), EIA
  • Myocardial Antibody, IFA
  • Parietal Cell Antibody, MAID
  • Rheumatoid Factor, NEPH
  • Ribosomal P Antibody, MAID
  • RNP Antibody IgG, MAID
  • Scl-70 Antibody IgG, MAID
  • Sm Antibody IgG, MAID
  • SS-A (Ro) Antibody IgG, MAID
  • SS-B (La) Antibody IgG, MAID
  • Striational Muscle Antibody, IFA
  • Thyroid Peroxidase (TPO) Antibody, MAID

Confirmation testing may be performed at an additional charge.
Methodology ELISA (Enzyme Linked Immunosorbent Assay), IFA (Immunofluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range By report
Preferred Specimen 4 mL serum
(minimum 2 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 83516 x 4; 86039; 86160 x 2; 86225; 86235 x 5; 86255 x 2; 86376; 86431
(add 86235 for each confirmation)
 
22202
Lupus Expanded Panel (C4) print

See individual assay for description.

Panel Includes:

  • Actin (Smooth Muscle) IgG, ELISA
  • ANA IFA Screen with Reflex to Titer and Pattern
  • C4, Complement NEPH
  • dsDNA Antibody, MAID
  • Mitochondria M2 Antibody (IgG), EIA
  • Myocardial Antibody, IFA
  • Parietal Cell Antibody, MAID
  • Ribosomal P Antibody, MAID
  • RNP Antibody IgG, MAID
  • Scl-70 Antibody IgG, MAID
  • Sm Antibody IgG, MAID
  • SS-A (RO) Antibody IgG, MAID
  • SS-B (La) Antibody IgG, MAID
  • Striational Muscle Antibody, IFA
  • Thyroid Peroxidase (TPO) Antibody, MAID

Methodology ELISA (Enzyme Linked Immunosorbent Assay), IFA (Immunofluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range By report
Preferred Specimen 4 mL serum
(minimum 2 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 83516 x 4; 86039; 86160; 86225; 86235 x 7; 86255 x 2; 86376
 
22250
Lupus Panel print

See individual assay for description.

Panel Includes:

  • ANA IFA Screen with Reflex to Titer and Pattern
  • C3, NEPH
  • C4, NEPH
  • dsDNA Antibody, MAID
  • RNP Antibody IgG, MAID
  • RNP/Sm Antibody IHA Titer
  • Scl-70 Antibody IgG, MAID
  • Sm Antibody IgG, MAID
  • Sm Antibody IHA Titer
  • SS-A (Ro) Antibody IgG, MAID
  • SS-B (La) Antibody IgG, MAID
  • Thyroid Peroxidase (TPO) Antibody, MAID
  • Rheumatoid Factor, NEPH
  • Ribosomal P Antibody, MAID

Methodology IFA (Immunofluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range By report
Preferred Specimen 4 mL serum
(minimum 2 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 83516; 86039; 86160 x 2; 86225; 86235 x 7; 86376; 86431
 
2280
Lupus Panel II print

See individual assays for description.

Panel Includes:

  • Anti-Nuclear Antibody (ANA) (HEP-2 Substrate), IFA
  • C3 Complement, NEPH
  • C4 Complement, NEPH
  • dsDNA Antibody, MAID
  • Rheumatoid Factor, NEPH
  • RNP Antibody IgG, MAID
  • Scl-70 Antibody IgG, MAID
  • Sm IgG Antibody, MAID
  • SS-A and SS-B IgG Antibodies, MAID

Methodology IFA (Immufluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range By report
Preferred Specimen 3 mL serum
(minimum 2 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 86039; 86160 x 2; 86225; 86235 x 7; 86431
 
42300
Lyme Disease (B. burgdorferi) DNA, Qualitative Real-Time PCR, Blood print

Detection of Borrelia burgdorferi DNA in clinical specimens can aid in the diagnosis of Lyme disease in suspected patients. This real-time PCR assay uses primers and probe that do not cross-react with other tick-borne pathogens.

This test is approved for New York patient testing.
Methodology REAL-TIME PCR
Reference Range Not detected
Preferred Specimen 1 mL whole blood (EDTA, ACD)
(minimum 0.5 mL)
Transport Temperature Room temperature
Results Available 1 to 3 days
CPT Code 87476
 
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22260
Lupus Panel without Rheumatoid Factor print

See individual assay for description.

Panel Includes:

  • ANA IFA Screen with Reflex to Titer and Pattern
  • C3, NEPH
  • C4, NEPH
  • dsDNA Antibody, MAID
  • Ribosomal P Antibody, MAID
  • RNP Antibody IgG, MAID
  • RNP/Sm Antibody IHA Titer
  • Scl-70 Antibody IgG, MAID
  • Sm Antibody IgG, MAID
  • Sm Antibody IHA Titer
  • SS-A (Ro) Antibody IgG, MAID
  • SS-B (La) Antibody IgG, MAID
  • Thyroid Peroxidase (TPO) Antibody, MAID

Methodology IFA (Immunofluorescence Assay), MAID (Multi-Analyte Immunodetection) and Nephelometry
Reference Range <100 U/mL
Preferred Specimen 4 mL serum
(minimum 2 mL)
Transport Temperature 2-8° C
Results Available 1 to 5 days
CPT Code 83516; 86039; 86160 x 2; 86225; 86235 x 7; 86376
 
42400
Lyme Disease (B. burgdorferi) DNA, Qualitative Real-Time PCR, CSF/SF print

Detection of Borrelia burgdorferi DNA in clinical specimens can aid in the diagnosis of Lyme disease in suspected patients. This real-time PCR assay uses primers and probe that do not cross-react with other tick-borne pathogens.

This test is approved for New York patient testing.
Methodology Real-Time PCR
Reference Range Not detected
Preferred Specimen 1 mL synovial fluid or CSF
(minimum 0.5 mL)
Transport Temperature 2-8° C
Results Available 1 to 3 days
CPT Code 87476
 
42200
Lyme Disease (B. burgdorferi) DNA, Qualitative Real-Time PCR, Tick print

Detection of Borrelia burgdorferi DNA in clinical specimens can aid in the diagnosis of Lyme disease in suspected patients. This real-time PCR assay uses primers and probe that do not cross-react with other tick-borne pathogens.

This test is approved for New York patient testing.
Methodology Real-Time PCR
Reference Range Not detected
Preferred Specimen Deer tick in 70% ethanol or in wet tissue in a sterile screw cap container
Transport Temperature Room temperature
Results Available 1 to 3 days
CPT Code 87476
 
-144
Lyme Disease (See Borrelia burgdorferi) print

 
42500
Lyme Disease (B. burgdorferi) DNA, Qualitative Real-Time PCR, Urine print

Detection of Borrelia burgdorferi DNA in clinical specimens can aid in the diagnosis of Lyme disease in suspected patients. This real-time PCR assay uses primers and probe that do not cross-react with other tick-borne pathogens.

This test is approved for New York patient testing.
Methodology Real-Time PCR
Reference Range Not detected
Preferred Specimen 4 mL random urine
(minimum 2 mL)
Transport Temperature FROZEN
Results Available 1 to 3 days
CPT Code 87476
 
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65534
Lyme Disease Antibodies (Serum and CSF), WB print

The Western blot detection of antibody to Borrelia burgdorferi antigens is intended for use as an ancillary test for serologic diagnosis of Lyme disease. It is especially useful for the evaluation of specimens yielding questionable results by IFA and/or ELISA. The early IgM and IgG response to B. burgdorferi is usually limited to the 41 kD flagellar protein. With time IgG antibodies are detected against numerous antigenic determinants of the spirochete. The criteria for a positive serum IgG Western blot requires the presence of antibody to at least five of ten specific Borrelia proteins; criteria for a positive serum IgM Western blot requires the presence of antibody to two of three specific proteins. No interpretive criteria for Borrelia burgdorferi Western blot have been established for CSF or other fluids. The presence of B. burgdorferi reactive antibodies in fluids may represent either compartmental antibody production or transudation of plasma antibody.

This test is approved for New York patient testing.
Methodology Western Blot
Reference Range Negative
Preferred Specimen 1 mL serum and CSF
(minimum 0.1 mL)
(both collected on the same day)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86617 x 4
 
20560
Lymphocyte Antibody, FC print

The detection of circulating lymphocyte antibodies is useful in characterizing autoimmune disorders involving destruction of lymphocytes resulting in lymphocytopenia. Such disorders include SLE and AIDS. In addition, isoimmune lymphocyte destruction may occur in transfusions with incompatibility of lymphocyte-specific antigens and HLA antigens.

This test is not approved for New York patient testing.
Methodology Flow Cytometry
Reference Range Negative
Preferred Specimen 2 mL serum
(minimum 0.5 mL)
Transport Temperature 2-8° C
Results Available 1 to 8 days
CPT Code 86021
 
23504
Lymphocyte Antigen Stimulation Screen-Candida, CC print

The antigen specific lymphocyte stimulation assay is used to asses antigen recognition and cell proliferation of lymphocytes in vitro. A positive response (>3) indicates prior exposure to that specific antigen. A decreased response to a specific antigen may reflect a lack of prior exposure to the specific antigen, a waning response to the antigen, or a general decrease in lymphoid reactivity due to either a primary or secondary deficiency. When assessing immune competence, lymphocyte stimulation by a single antigen should be interpreted with caution.

This test is available for New York patient testing.
Methodology Cell Culture
Reference Range >3
Preferred Specimen 20 mL heparinized blood
(minimum 10 mL). Specimens must be received <=24 hours post collection. Specimens accepted Monday through Friday noon.
Transport Temperature Room temperature.
DO NOT REFRIGERATE OR FREEZE.
Results Available 9 to 12 days
CPT Code 86353
 
24504
Lymphocyte Antigen Stimulation Screen, PPD, CC print

The antigen specific Lymphocyte stimulation assay is used to asses antigen recognition and cell proliferation of lymphocytes in vitro. A positive response(>3) indicates prior exposure to that specific antigen. A decreased response to a specific antigen may reflect a lack of prior exposure to the specific antigen, a waning response to the antigen, or a general decrease in lymphoid reactivity due to either a primary or secondary deficiency. When assessing immune competence, lymphocyte stimulation by a single antigen should be interpreted with caution.

This test is available for New York patient testing.
Methodology Cell Culture
Reference Range >3
Preferred Specimen 20 mL heparinized blood
(minimum 10 mL). Specimens must be received <=24 hours post collection. Specimens accepted Monday through Friday noon.
Transport Temperature Room temperature.
DO NOT REFRIGERATE OR FREEZE.
Results Available 9 to 12 days
CPT Code 86353
 
22504
Lymphocyte Antigen Stimulation Screen-Tetanus Toxoid, CC print

The antigen specific Lymphocyte stimulation assay is used to asses antigen recognition and cell proliferation of lymphocytes in vitro. A positive response(>3) indicates prior exposure to that specific antigen. A decreased response to a specific antigen may reflect a lack of prior exposure to the specific antigen, a waning response to the antigen, or a general decrease in lymphoid reactivity due to either a primary or secondary deficiency. When assessing immune competence, lymphocyte stimulation by a single antigen should be interpreted with caution.

This test is available for New York patient testing.
Methodology Cell Culture
Reference Range >3
Preferred Specimen 20 mL heparinized blood
(minimum 10 mL). Specimens must be received <=24 hours post collection. Specimens accepted Monday through Friday noon.
Transport Temperature Room temperature.
DO NOT REFRIGERATE OR FREEZE.
Results Available 9 to 12 days
CPT Code 86353
 
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2554
Lymphocyte Mitogen and Antigen Stimulation, CC print

See individual assay for description.

Panel Includes:

  • Lymphocyte Antigen Stimulation Screen - Candida, CC
  • Lymphocyte Antigen Stimulation Screen - PPD, CC
  • Lymphocyte Antigen Stimulation Screen - Tetanus Toxoid, CC
  • Lymphocyte Mitogen Screen
This panel of assays can help assess the immunocompetence of an individual by measuring the immune response to specific mitogens and antigens.
Methodology Cell Culture
Reference Range By report
Preferred Specimen 20 mL whole blood, heparinized. Specimen must be received within 24 hours of collection, Monday through Friday, by noon.
Transport Temperature Room temperature
Results Available 6 to 12 days
CPT Code 86353 x 6
 
2254
Lymphocyte Mitogen and 2-Antigen Screen print

See individual assay for description.

Panel Includes:

  • Lymphocyte Antigen Stimulation Screen-Tetanus Toxoid, CC
  • Lymphocyte Antigen Stimulation Screen-Candida, CC
  • Lymphocyte Mitogen Screen, CC

Methodology CC (cell culture)
Reference Range By report
Preferred Specimen 20 mL heparinized blood sent to lab within 24 hours of collection.
(minimum 10 mL)
Specimens are accepted Mon. through Fri. Noon.
Transport Temperature Room temperature
Results Available 6 to 12 days
CPT Code 86353 x 5
 
20630
Lymphocyte Mitogen Response-Rapid Assay print

This unit code has been inactivated.

Please see unit code 20392.
 
20392
Lymphocyte Mitogen Screen, CC print

Lymphocyte responsiveness to concanavalin A, phytohemagglutinin and pokeweed mitogen is determined. Impaired responses to these mitogens are encountered in immunodeficiency diseases, certain infections and possibly in cancer. The mitogen screen may be utilized in conjunction with the T and B cell values to assess the immunocompetence of an individual.

This test is available for New York patient testing.
Methodology Cell Culture
Reference Range By report
Preferred Specimen 20 mL heparinized blood (two green top Vacutainers)
(minimum 3 mL)
Due to the labile nature of lymphocytes, the specimen must be drawn and immediately sent to Focus. The specimen must be received <=24 hours post collection to ensure accurate results. Specimens accepted Monday through Friday noon.
Transport Temperature Room temperature.
DO NOT REFRIGERATE OR FREEZE.
Results Available 6 to 9 days
CPT Code 86353 x 3
 
20378
Lymphocyte Subset Panel 1 print

See individual assay for description.

Panel includes:
  CD4, CD8, CD3, CD19 and CD16/56.


Test performed at Quest Diagnostics Nichols Institute.
Methodology Flow Cytometry
Reference Range By report
Preferred Specimen 5 mL whole blood (EDTA)
(minimum 0.5 mL)
Transport Temperature Room temperature.
DO NOT REFRIGERATE OR FREEZE.
Results Available 2 to 4 days
CPT Code 86355; 86357; 86359; 86360
 
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-145
Lymphocyte Phenotyping, FC
(See the specific Lymphocyte Phenotyping Profile desired: T and B Cells; T Cell Subsets; T Cells, B Cells, T Cell Subsets) 		print

 
40625
Lymphocytic Choriomeningitis (LCM) Virus Antibody, IFA (Serum) print

Antibody to LCM is often detectable within a few days of clinical symptoms. An elevated IgM titer provides a rapid diagnosis of recent or current infection. A four-fold rise in IgG titer between acute and convalescent specimens is also considered diagnostic of recent infection.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range IgG <1:16
IgM <1:20
Preferred Specimen 1 mL serum
(minimum 0.075 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727 x 2
 
60625
Lymphocytic Choriomeningitis (LCM) Virus Antibody, IFA (CSF) print

Detection of intrathecally-produced organism-specific antibodies in CSF indicates central nervous system infection. However, serum levels of organism-specific antibodies, blood-brain barrier integrity, and possible CSF contamination by blood should be considered when assessing CSF results.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range IgG <1:1
IgM <1:1
Preferred Specimen 1 mL CSF
(minimum 0.1 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727 x 2
 
40630
Lymphocytic Choriomeningitis (LCM) Virus IgG Antibody, IFA (Serum) print

Antibody to LCM is often detectable within a few days of clinical symptoms. An elevated IgM titer provides a rapid diagnosis of recent or current infection. A four-fold rise in IgG titer between acute and convalescent specimens is also considered diagnostic of recent infection.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range <1:16
Preferred Specimen 1 mL serum
(minimum 0.075 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727
 
60630
Lymphocytic Choriomeningitis (LCM) Virus IgG Antibody, IFA (CSF) print

Detection of intrathecally-produced organism-specific antibodies in CSF indicates central nervous system infection. However, serum levels of organism-specific antibodies, blood-brain barrier integrity, and possible CSF contamination by blood should be considered when assessing CSF results.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range <1:1
Preferred Specimen 1 mL CSF
(minimum 0.25 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727
 
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40635
Lymphocytic Choriomeningitis (LCM) Virus IgM Antibody, IFA (Serum) print

Antibody to LCM is often detectable within a few days of clinical symptoms. An elevated IgM titer provides a rapid diagnosis of recent or current infection. A four-fold rise in IgG titer between acute and convalescent specimens is also considered diagnostic of recent infection.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range <1:20
Preferred Specimen 1 mL serum
(minimum 0.075 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727
 
60635
Lymphocytic Choriomeningitis (LCM) Virus IgM Antibody, IFA (CSF) print

Detection of intrathecally-produced organism-specific antibodies in CSF indicates central nervous system infection. However, serum levels of organism-specific antibodies, blood-brain barrier integrity, and possible CSF contamination by blood should be considered when assessing CSF results.

This test is available for New York patient testing.
Methodology IFA (Immunofluorescence Assay)
Reference Range <1:1
Preferred Specimen 1 mL CSF
(minimum 0.1 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86727
 
23005
Lymphogranuloma Venereum (LGV) Differentiation Antibody Panel, MIF (Serum) print

Lymphogranuloma venereum (LGV) is a clinical syndrome caused by infection with serovars L1, L2, or L3 of C. trachomatis. Due to the highly crossreactive nature of the C. trachomatis (L2) antigen used in this panel, antibodies induced by infection with C. trachomatis (D-K) or other chlamydial species often show strong L2 reactivity. Thus, detection of L2-reactive antibodies does not necessarily indicate infection with LGV serovars of C. trachomatis. Results for the whole Chlamydia antibody panel should be considered in conjunction with clinical findings to establish the diagnosis.

This test is available for New York patient testing.
Methodology MIF (Micro Immunofluorescence)
Reference Range IgG <1:64
IgA <1:16
IgM <1:10
Preferred Specimen 1 mL serum
(minimum 0.25 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86631 x 8; 86632 x 4
 
63005
Lymphogranuloma Venereum (LGV) Differentiation Antibody Panel, MIF (CSF) print

Detection of intrathecally-produced organism-specific antibodies in CSF indicates central nervous system infection. However, serum levels of organism-specific antibodies, blood-brain barrier integrity, and possible CSF contamination by blood should be considered when assessing CSF results.

This test is available for New York patient testing.
Methodology MIF (Micro Immunofluorescence)
Reference Range By report
Preferred Specimen 1 mL CSF
(minimum 0.5 mL)
Transport Temperature 2-8° C
Results Available 1 to 4 days
CPT Code 86631 x 8; 86632 x 4
 
 
First FDA Clearance of a 2009 H1N1 Test Given to Focus Diagnostics


FDA Issues Another Emergency Use Authorization for Commercial H1N1 Flu Test to Quest Diagnostics’ Focus Diagnostics


Focus Diagnostics provides the first commercial test for detecting the 2009 H1N1 influenza virus that the FDA has authorized for emergency use.


Focus Diagnostics receives NYSDOH exemption for Diagnostic Immunology and Serology testing services


Focus Diagnostics Launches Laboratory Test for Chikungunya Virus


 
   
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